1-(4-溴苯基)丙烯酮的新方法合成

A novel approach to synthesize 1-(4-bromo-phenyl)-propenone

摘要:

摘要：以溴苯为起始原料，经酰化、消去反应得到纯度95%以上的精细化工中间体1-(4-溴苯基)丙烯酮，目标化合物经1HNMR、IR及GC-MS表征。探讨了酰化及消去反应的最佳反应条件。条件实验表明，当n(3-氯丙酰氯):n(溴苯):n(三氯化铝)=1.3:1:1.5，反应温度20～25 ℃时，酰化反应效果最佳；当以醋酸钾做碱，n[4-(3-氯丙酰基)溴苯]:n(醋酸钾)=1:1.5，反应温度20～25 ℃时，消去反应效果最佳。

Abstract:

Abstract：More than 95% purity of fine chemical intermediates of 1-(4-bromo-phenyl)-propenone was synthesized via Friedel-Crafts and elimination reaction with bromobenzene as the starting material. The target compound was characterized by 1HNMR、IR and GC-MS. The best reaction conditions of Friedel-Crafts and elimination reaction were investigated. The results of condition experiments showed that when n(3-chloropropionyl chloride):n(bromobenzene):n(aluminium chloride)=1.3:1:1.5, and the reaction temperature was 20～25 ℃, the reaction effect of Friedel-Crafts was best. With potassium acetate as the base, when n[1-(4-bromo-phenyl)-3-chloro-propan-1-one]: n[potassium acetate]=1:1.5, and the reaction temperature was 20～25 ℃, the reaction effect of elimination reaction was best.