N-(甲酰基吡嗪)-α-氨基酸甲酯的合成

Synthesis of N-(formyl pyrazine)-α-amino Acid Methyl Esters

摘要:

摘要：以2,3-吡嗪二羧酸和α-氨基酸（甘氨酸、缬氨酸、亮氨酸）为原料，在氯化亚砜的作用下，采取分步法和一步法，得到不同的吡嗪酰胺类衍生物，其结构经1H NMR、13C NMR、IR和HR MS等方法确定。探讨了不同反应条件对吡嗪酰胺类衍生物合成的影响。结果表明：在氯化亚砜的作用下，采用分步法和一步法，分别得到N-(2-羧基-3-甲酰基吡嗪)-α-氨基酸甲酯和N-(2,3-二甲酰基吡嗪)- α-氨基酸甲酯。

Abstract:

Abstract: Under the action of the thionyl chloride, different pyrazinamide derivatives were gotten from 2, 3 - pyrazinedicarboxylic acid and α-amino acids (glycine, valine, leucine) by fractional steps and one-step. Its structure was confirmed by 1H NMR, 13C NMR, IR and HR MS spectral analysis. The effect of different reaction conditions on the synthesis of pyrazinamide derivatives was discussed. The results showed that: In the presence of thionyl chloride, N-(2-carboxy-3-formyl-pyrazine)-α-amino acid methyl ester and N-(2, 3-acyl dimethyl pyrazine)-α-amino acid methyl esters were obtained by the sub-step or step, respectively.