钌(Ⅱ) 杂环醛苯甲酰腙配合物的合成、表征及生物活性

Synthesis, characterization and biological activities of Ru(II)–dmso complexes with heterocyclic hydrazones ligands

摘要:

本文用cis-[Ru(Ⅱ)Cl2(DMSO)4]和杂环醛苯甲酰腙为原料，合成2个[Ru(Ⅱ)Cl2(DMSO)2L1，2]型(L1为 4-吡啶甲醛苯甲酰腙，L2为2-呋喃甲醛苯甲酰腙)配合物。通过元素分析、红外光谱、紫外光谱和核磁共振氢谱对配合物结构进行了表征，利用循环伏安法研究了配合物的电化学性质，并用打孔琼脂扩散法检测了配合物的抑菌效果。用MTT法测试了配合物对人肺癌细胞株A549的抑制活性，IC50值为195.79μg/mL。

Abstract:

Two [Ru(Ⅱ)Cl2(DMSO)2L1,2] type complexes were synthesized by mixing precursor complex cis-[RuCl2(DMSO)4] and heterocyclic aldehyde benzoyl hydrazone in ethanol (L1 is pyridine-4-formaldehyde benzoylhydrazone, L2 is furan-2-carboxaldehyde benzoylydrazone) .The new complexes were characterized by elemental analysis, IR spectra , UV-Vis spectra and 1HNMR. The electrochemical behavior of the complexes was studied with the help of cyclic voltammetry, Results indicate that [Ru(Ⅱ)Cl2(DMSO)2L2)] of five strains were used in the experiment has strong antibacterial activity.The antibacterial activity of complexes was detected by agar diffusion method and the anticancer activity of complexes was detected by MTT method, Results showed [Ru(Ⅱ)Cl2(DMSO)2L1] expression of growth promoting effect on cells, [Ru(Ⅱ)Cl2(DMSO)2L2)]Show the promotion before inhibition effect.