反-4-(反-4′-正丙基环己基)-环己基甲醛的合成与表征

Synthesis and characterization of trans-4-(trans-4′-n-propylcyclohexyl)cyclohexyl aldehyde

摘要:

摘要：以反-4-(4′-正丙基环己基)-苯甲醛丙二醇缩醛为起始原料，经加氢、酸解及异构化反应得到纯度98%以上的反-4-(反-4′-正丙基环己基)-环己基甲醛，总收率为39.2%，目标化合物的结构经1HNMR、IR及GC-MS确认。探讨了反-4-(4′-正丙基环己基)-苯甲醛丙二醇缩醛加氢的反应条件，条件实验表明：以钌/碳做催化剂，乙醇做反应溶剂，当m[反-4-(4′-正丙基环己基)-苯甲醛丙二醇缩醛]:m(钌/碳)=1 g : 0.09 g，加氢压力为3.5 MPa，反应温度为35～40 ℃时，反应效果最佳。

Abstract:

Abstract：More than 98% purity of trans-4-(trans-4′-n-propylcyclohexyl)cyclohexyl aldehyde was obtained via hydrogenation,acidolysis and isomerization reaction with trans-4-(4′- n-propylcyclohexyl)-benzaldehyde propylene glycolacetal as the starting material, the total yield was 39.2%, the structure of the target compound was confirmed by 1HNMR, IR and GC-MS. The hydrogenation reaction conditions of trans-4-(4′-n-propylcyclohexyl)-benzaldehyde propylene glycolacetal were investigated,the results of the condition experiments showed that the reaction effect was best when Ru/C was as the catalyst, ethanol was as the reaction solvent,m[trans-4-(4′- n-propylcyclohexyl)-benzaldehyde propylene glycolacetal]:m(Ru/C) was 1 g : 0.09 g,the hydrogenation pressure was 3.5 MPa,the reaction temperature was 35～40 ℃.