pH和CO2响应性嵌段共聚物的合成及其自组装行为的研究

Studies on Synthesis and Self-assembly Behavior of pH and CO2-Responsive Block Copolymers

摘要:

采用可逆加成-断裂链转移自由基聚合（RAFT）和开环聚合（ROP）合成一种具有多重敏感性的聚甲基丙烯酸N,N-二甲氨基乙酯-b-聚乳酸（PDMAEMA-b-PLA）嵌段共聚物。利用傅里叶变换红外光谱（FTIR）、核磁共振（1H-NMR）对双亲性嵌段共聚物的结构进行表征；用紫外-可见分光光度计（UV-Vis）、Zeta电位及粒度分析仪和扫描电子显微镜（SEM）研究了其自组装行为及聚集体的大小、形态变化，结果表明，嵌段共聚物在酸性和中性条件下有pH敏感性和CO2响应性，且具有良好的可逆性。

Abstract:

Multi-responsive block copolymer poly(dimethylamino-2-ethyl methacrylate)-block-poly(lactide) (PDMAEMA-b-PLA) was synthesized by Ring-opening Polymerization (ROP) and Reversible Addition-Fragmentation Chain Transfer Polymerization (RAFT). Structures of the block copolymers were conformed by 1H-NMR and FTIR. The self-assembly of the block copolymers and their particle sizes and morphologies changed with CO2 and pH responses were investigated by ultraviolet spectrophotometer (UV-Vis), zeta potential and particle size analyzer and SEM. Results showed that the block copolymers have pH sensitivity and CO2 responsibility, and the responsibilities to environment can be recycled at least three times.