SA/FK智能复合微球的交互作用及溶胀性能

The interactions and swelling properties of sodium alginate/feather keratin intelligent microspheres

摘要:

采用挤压法制备了海藻酸钠/羽毛蛋白（SA/FK）复合微球。用FTIR和黏度法研究了SA/FK体系的交互作用、探讨了不同制备条件（FK用量、交联剂质量分数、交联时间）、溶胀溶液性质（pH、温度、离子强度）对溶胀性能的影响。结果表明，复合体系的交互作用是静电为主，氢键次之。随着时间延长，溶胀速率变缓，最终达到溶胀平衡。当m（FK）: m（SA）=0.60、w（CaCl2）= 7%、交联时间为60min时，复合微球网络结构最紧密，溶胀速率最低，平衡溶胀率分别为0.6、0.6、0.9。pH由1增加至 7，平衡溶胀率仅从0.9升至1.1，当pH=13时，平衡溶胀率升至3.8。温度由30℃提高至45℃，平衡溶胀率从0.6升至0.9。离子强度由0增加至0.6mol/L，平衡溶胀率从1.1升至13.8。 SA/FK复合微球具有pH/温度/离子强度敏感性，有望实现新型智能缓释微球的开发。

Abstract:

Sodium alginate/feather keratin（SA/FK） microspheres were prepared by extrusion dripping method. The interactions of SA and FK were charactered by FTIR and viscosimetry. The effects of preparation conditions（m（FK）: m（SA）, w（CaCl2）, crosslinking time）and solution properties（pH, temperature, ionic strength,）on swelling ratio were also investigated. The result indicates that, electrostatic is the main interaction and hydrogen bond supplements it. Over time, swelling rate becomes slow, and it meets equilibrium swelling at last. SA/FK microspheres have compact network structures when m（FK）: m（SA）=0.60, w（CaCl2）= 7% and crosslinking time is 60 min. The equilibrium swelling ratios are 0.6, 0.6, and 0.9. The equilibrium swelling ratio rises from 0.6 to 0.9 when temperature rises from 30℃ to 45℃. The equilibrium swelling ratio rises from 0.9 to 1.1 when pH froms 1 to 7. As pH=13, it rises to 3.8. The equilibrium swelling ratio rises from 1.1 to 13.8 when ionic strength increases from 0 to 0.6mol/L. SA/FK microspheres possess the ionic strength / temperature / pH sensitivity, and it is expected to achieve new intelligent slow-release microspheres.