间苯二甲醛的合成

Synthesis of Isophthalaldehyde

摘要:

以间苯二甲胺和乌洛托品为原料，通过控制反应的pH合成间苯二甲醛。适宜工艺条件为：间苯二甲胺与乌洛托品的摩尔比为1∶4.5、反应温度104℃、反应时间4h、pH=3～4，在该条件下，收率达76.2%。经IR、1HNMR和ESI-MS表征了产物的结构，确认所得产物即为目标产物，其指标达到国际上对该产品的质量要求，经HPLC测定其色谱纯度为99.7%。

Abstract:

Isophthalaldehyde was prepared from m-xylylenediamine and hexamethylenetetramine under the control of the reaction pH. The optimum conditions for the synthesis were as follows: n(MXDA):n(HMT)=1:4.5, temperature 104℃, time 4h,pH 3～4, yield 76.2%. FTIR and 1HNMR and ESI-MS analysis identified the desired product. The product properties reached the international quality standards，and detected by HPLC, the purity of the target product was 99.7%.