微通道反应器中合成碘代芳烃

Synthesis of iodo-substitued aromatic compounds in a micro-channel reactor

摘要:

研究了在自制聚四氟管微通道反应器内，取代芳胺重氮盐和碘化钾反应连续合成碘代芳烃的工艺过程。以碘苯为模型底物，考察了管道内径、体积流速、停留时间、反应温度等对反应的影响，得到最佳的工艺条件为：管道内径0.8mm，体积流速1004.8μL/min，停留时间75s，反应温度20℃。在该条件下，碘苯产率为79.0%，时空转化率为9.41?03 mol?m?3?h?1，比常规反应高出两个数量级。在上述最佳工艺条件下，分别研究了其他碘代芳烃在微通道反应器内的合成。

Abstract:

The process for preparation of iodo-substitued aromatic compounds by iodination of diazonium salt and potassium iodide was investigated in self-made PTFE-microreactor. The effects of the inner diameter of microchannel reactors, current, capacity resident time and reaction temperature on yield were performed. The optimum conditions were determined as follows: the inner diameter of micro-channel reactors 0.8mm, total flow rate 1004.8μL/min, reaction temperature 20℃, reaction time 75s. The yield of iodobenzene was 79.0% under these conditions. The STC in micro-channel reactor was 9.41?03 mol?m?3?h?1, more than 100 times of that in a regular reactor. The optimum reaction conditions were also applied in the preparation of other iodo-substitued aromatic compounds in microreactor.