聚乳酸膜辐照接枝PVP的表面性能及细胞毒性研究

Gamma Ray Induced Graft Polymerization of PVP on PLA Surface and

摘要:

研究利用γ射线辐照在聚乳酸膜表面接枝亲水性的聚N-乙烯基吡咯烷酮（PVP）来改善材料的亲水性和细胞相容性，使用红外光谱(FT-IR) 、扫描电镜(SEM) 、差示量热扫描仪(DSC) 对接枝前后的聚乳酸膜进行测试，并利用接触角和吸水率分析了聚乳酸膜亲水性的变化。测试结果表明接枝的PVP可以改善材料的亲水性，接枝率为16.4%的接枝共聚物吸水率较纯PLA提高了13.3倍，接触角下降了8?；细胞毒性试验结果表明，改性后的接枝共聚物无细胞毒性，并且与聚乳酸的浸提液101.9%的细胞存活率相比，接枝共聚物50%和100%的浸提液的细胞存活率分别为109.3%和107.4%，表明接枝后的材料具有良好的细胞相容性，且更有利于细胞的生长。

Abstract:

Gamma ray graft polymerization was used in this paper to improve the hydrophilicity and cell compatibility of PLA. The materials were investigated by FT-IR, SEM, DSC analysis, water contact angle measurement and water uptake test. The results showed that the modified materials had better hydrophilicity and the contact angle was decreased 8癮nd the water uptake was increased 13.3 times after graft polymerization. The cytotoxicity experiment was carried out to evaluate the biocompatibility of the grafted copolymer. The result indicated that the grafted material has no cytotoxicity and has better biocompatibility; the cell survival rate was 109.3% of 50% leaching liquor and 107.4% of 100% leaching liquor.