2-巯基丙酸/β-环糊精包合物的制备及表征

Preparation and characterization of 2-mercaptopropionic acid / β-cyclodextrin inclusion compound

摘要:

摘要：采用饱和水溶液法制备2-巯基丙酸/β-环糊精包合物，利用紫外分光光度法测定包合物中2-巯基丙酸的含量，并通过正交实验对其包合工艺进行优化，结果表明：β-环糊精:2-巯基丙酸=12:1 (质量比)、包合温度为45℃、包合时间为4h时，包合效果最好，包合率达到74.95％。并利用数码液晶生物显微镜法、扫描电镜法、紫外分光光度法、红外光谱法对包合物的形成进行了验证。

Abstract:

Abstract:The β-cyclodextrin inclusion compound of 2-Mercaptopropionic acid was prepared by saturated water solution method,the content of 2-Mercaptopropionic acid of inclusion compound were tested by ultraviolet spectrophotometry and the synthesis process was optimized by orthogonal experimental design ,the results show that the most optimized conditions were as following:β-cyclodextrin:2- Mercaptopropionic acid =12:1 (Mass ratio); the inclusion temperature was 45 ℃; the inclusion time was 4h; the inclusion rate can reach 74.95%;then the structure of the inclusion complex was characterized by digital liquid crystal biological microscope, scanning electron microscope, ultraviolet spectrophotometry and infrared spectroscopy.