含二茂铁基吡唑啉的合成及其抗真菌活性

Synthesis and Antifungal Activity of Pyrazoline Containing Ferrocenyl

摘要:

以二茂铁为起始原料，首先用合成的乙酰基二茂铁与醛反应，合成1-二茂铁基-3-(4-R1苯基)-2-丙烯酮，然后再与水合肼反应合成吡唑啉，最后通过与酰氯反应生成一系列N-酰基-3-二茂铁基-5-芳基吡唑啉化合物。通过1HNMR、FTIR及ESI-HRMS进行了目标化合物结构的表征；最后，将合成的吡唑啉化合物分别对4种植物真菌病（小麦赤霉病、马铃薯干腐病、烟草赤星病、西瓜枯萎病）进行了初步的抗植物真菌活性实验，测试结果显示，部分化合物具有良好的抗植物真菌活性。

Abstract:

A series of pyrazoline derivatives were designed and synthesized from acetylferrocene, benzaldehyde, hydrazine hydrate and acyl chloride. The structures of the target compounds were confirmed by 1HNMR, FTIR and ESI-HRMS. Finally，the primary antimycotic activity of the title compounds against four plant fungals (Gibberlla saubinetii, Pythium solani, Gibberlla nicotiancola, Fusarium oxysporium f.s.p. niveum.) had been screened. The final results indicate that some of the compounds have a good plant anti-fungal activity.