3,3,6,6-四甲基-9-喹啉基-2,4,5,7,9,10-六氢化吖啶-1,8(2H,5H)-二酮衍生物的合成、晶体结构

Synthesis, Crystal Structure of 3,3,6,6-Tetramethyl-9- quinolyl-2,4,5,7,9,10- hexahydroacridine-1,8(2H,5H)-dione

摘要:

由2-氯喹啉-3-甲醛及衍生物、双甲酮和醋酸铵在温和的条件下在醋酸中生成一系列高收率的新的化合物3,3,6,6-四甲基-9-喹啉基-2,4,5,7,9,10-六氢化吖啶-1,8(2H,5H)-二酮衍生物，并培养成单晶。通过元素分析、红外分析、核磁氢谱、质谱和X射线单晶衍射对其结构进行了表征。测得晶体3a属单斜晶系，空间群为Pccn，晶胞参数为a=2.2291（4）nm, b=1.1923（2）nm, c=1.7274（3）nm, α=β=γ=90? Dc =1.199g/cm3。该合成方法具有操作简便，反应时间短，不使用催化剂，产率高等优点。

Abstract:

Novel six compounds of 3,3,6,6-tetramethyl-9- quinolyl-2,4,5,7,9,10- hexahydroacridine-1,8(2H,5H)-dione were synthesized through the multi-component reaction of 2-chloroquinoline-3-carbaldehyde, dimedone and ammonium acetate in 83%～93% yield under mild condition, and was subsequently cultured into a single crystal. The compound was characterized by means of elemental analysis, IR , 1H NMR, MS and the crystal structure was determined by X-ray single crystal diffraction. The results show that the crystal 3a belongs to the monoclinic system with space group Pccn, with a=2.2291（4）nm, b=1.1923（2）nm, c=1.7274（3）nm, α=β=γ=90°, Dc =1.199g/cm3.