功能纳米聚合物的合成及其阳离子化产物的抗菌性

Synthesis and Antibacterial Activities of catinized Organic Nanopolymers

摘要:

以丙烯酸甲酯（MA）和甲基丙烯酸缩水甘油酯（GMA）为单体、乙二醇二甲基丙以丙烯酸甲酯（MA）和甲基丙烯酸缩水甘油酯（GMA）为单体、乙二醇二甲基丙烯酸酯（EGDMA）为交联剂、十二烷基硫酸钠（SDS）为乳化剂, 改变单体进料n(GMA)/n(MA)值，合成了5种带环氧基的有机纳米聚合物(ONPs), ONPs与三甲胺盐酸盐反应制得阳离子化聚合物(CONPs)。利用红外光谱（FT-IR）、粒径分析、电荷密度测定和热重分析（TGA）对ONPs与CONPs进行了表征；采用显微观察与烧瓶振荡法研究了CONPs对大肠杆菌和金黄色葡萄球菌的抗菌性。结果表明，CONPs是带有正电荷的微粒；ONPs与CONPs的热稳定性良好；CONPs的平均粒径和抗菌性随配方中GMA用量增大而增加。

Abstract:

With methacrylate (MA) and glycidyl methacrylate (GMA) as monomers, ethylene glycol dimethacrylate (EGDMA) as crosslinker, and sodium dodecylsulfate (SDS) as emulsifier, varying the feed ratio of n(GMA)/n(MA), five epoxy-containing organic nanopolymers (ONPs) were synthesized by emulsion polymerization method. The cationized organic nanopolymers (CONPs) were prepared by reacting ONPs with trimethylamine hydrochloride. FT-IR, particle size measurement, charge density determination, and TGA were used to characterize the structures of ONPs and CONPs. The antimicrobial properties of CONPs against E. coli and S. aureus were investigated by biological microscope and flask-shaking method. The results show that CONPs are particles with positive charges. ONPs and CONPs have good thermal stability. The mean diameters and antimicrobial activities of CONPs increase with increasing the amount of GMA in recipes.