微流体技术制备粒径可控且均一的SDB-TPGDA多孔微球

Synthesis of size-controlled and uniform SDB-TPGDA porous microspheres by microfluidic technology

摘要:

设计构建了可拆装的毛细管基微流体控制系统用于制备具有高度单分散性（CV值为3.78%）的苯乙烯（St）/二乙烯基苯（DVB）/三缩丙二醇双丙烯酸酯（TPGDA）多孔共聚物微球。所制备的单分散性多孔微球在直径250～1550 μm通过调控分散相与连续相流量比及连续相黏度实现粒径精准可控。采用光引发聚合实现具有优良球形度微球（Max.D./Min.D.小于1.05）的快速在线制备，光引发聚合速率随着TPGDA在混合单体中质量的增加而增加。该研究提供了一种有效制备单分散性大粒径聚苯乙烯类多孔微球方法。

Abstract:

An assembly-disassembly capillary-based microfluidic system was demonstrated for fabricating highly monodisperse (CV = 3.78%) poly(styrene-co-divinylbenzene-co-TPGDA) porous microspheres. The size of as-prepared ploy(SDB-TPGDA) microspheres can be precisely controlled in the size range of 250～1550 μm by manipulating flow rates radio of continuous phase to dispersed phase and continuous phase viscosity. Polymer microspheres with good sphericity （Max.D./Min.D. ＜ 1.05）were fast prepared by photopolymerization. The rate of photopolymerization increased rapidly with the increases of the TPGDA content of the mixed monomer. This study provided an effective approach to the synthesis of monodisperse polystyrene-base porous microspheres with large particle size.