肟菌酯关键中间体的合成研究

Study on the Synthesis of Pivotal Intermediate of Trifloxystrobin

摘要:

以邻甲基苯乙酮为原料，依次经相转移催化下的高锰酸钾碱性氧化、甲醇酯化、甲氧胺盐酸盐肟化和N-溴代丁二酰亚胺（NBS）溴化后，得到制备肟菌酯的关键中间体——(E)-2-(2'-溴甲基苯基)-2-羰基乙酸甲酯-O-甲基酮肟。产品结构经熔点和1H-NMR表征。通过优化反应条件，总收率可达52%。

Abstract:

The pivotal intermediate (E)-methyl 2-(2-(bromomethyl)phenyl)-2-(methoxyimino)acetate of Trifoxystrobin was synthesized from 2-methylacetophenone via a serial of reactions included alkaline oxidation with potassium permanganate in the presence of the phase-transfer catalyst, esterification with methanol, oximation with methoxyamine hydrochloride, bromination with N-bromosuccinimide (NBS). The structure was characterized by melting point and 1H-NMR. Under the optimized reaction conditions, the total yield was 52%.