4-二甲胺基吡啶合成新工艺研究

synthesis process research of DMAP

摘要:

4-二甲氨基吡啶（简称DMAP）是一种应用广泛的催化剂，被广泛的应用于多种有机反应当中，被称为超级催化剂。论文研究以4-氰基吡啶和苯乙烯为原料制备DMAP新工艺。优化得到反应条件为4-氰基吡啶与苯乙烯摩尔比为1:1.2，使用40 %氢氧化钠水溶液回流2h裂解中间体，并回收了苯乙烯，反应产率达73.8 %。产品通过核磁、红外和元素分析等确认产品结构。

Abstract:

4-dimethylaminopyridine (abbreviation DMAP) is a widely used catalyst in a variety of organic reactions, so it is called super-catalyst. In this article, we designed and researched a new synthesis route by Using 4-cyanopyridine and styrene as raw materials. The optimum conditiongs were given n(4-cyanopyridine)/ n(styrene)= 1:1.2, and w (40 %) sodium hydroxide solution was added to decompose the intermediate under reflux for 2h. The yield of the product reached 73.8% and styrene could be recovered. The structure of target compound was confirmed by IR, HNMR..