2, 3-吡嗪-二甲酸二顺6-壬烯酯的合成，热裂解分析及其卷烟加香应用

Synthesis of 2, 3-Pyrazine-Dicarboxylic Acid Cis 6-Nonenol Esters and its Application in Cigarette

摘要:

以顺6-壬烯醇和2, 3-吡嗪-二甲酸为原料，以环己基碳二亚胺（DCC）为缩水剂，在4-二甲氨基吡啶（DMAP）催化作用下，合成了2, 3-吡嗪-二甲酸二顺6-壬烯酯。其结构经IR, 1H NMR, 13C NMR, HRMS图谱对比得到验证，并对其进行了热裂解和卷烟加香实验。结果表明：(1)合成产物为目标产物；（2）裂解温度对合成产物的热裂解产物的种类和含量有较大影响，随着裂解温度的升高，裂解程度愈来愈剧烈；（3）目标产物在卷烟中的适宜用量为0.01%，目标产物加入到卷烟中后能够明显改善卷烟的吸食品质，协调烟香，减少刺激性和杂气，改善余味。

Abstract:

2, 3-Pyrazine-dicarboxylic acid cis 6-nonenol ester was synthesized from 2, 3-Pyrazine-dicarboxylic acid and cis 6-nonenol with 4-DMAP as catalyst and DCC as dehydration reagent. Its structure was confirmed by IR, 1H NMR, 13C NMR and HRMS spectra. The pyrolysis of the precursor and the application of the compound in blended cigarette flavoring were studied as well．The results showed that: (1) the synthetic product was the target compound. (2)Temperature had a great influence on the types and contents of pyrolysis of the compound；with the rise of pyrolytic temperature, the cracking degree become more and more severe．(3)Appropriate dosage of target compound in cigarette was 0.1‰, the compound can improve the smoking quality, harmonize the aroma, reduce irritation and odor and improve aftertaste.