邻茴香醛的绿色合成研究

Green synthesis of ortho anisic aldehyde

摘要:

利用廉价易得的邻羟基苯甲醛、伯胺及碳酸二甲酯等为原料，在温和条件下，采用了缩合、亲核取代及水解反应合成了目标化合物邻茴香醛。经过筛选实验研究，确定了合成邻茴香醛的最佳条件为：邻羟基苯甲醛缩正丁胺/DMSO/KOH/85℃/24h。与已见报道方法的收率60%-70%比较，该合成方法的收率有大幅度提高，最大收率达到了81%，并且该方法具有绿色、环保的特点。通过1H NMR、13C NMR谱及元素分析对产物进行了表征，结果与目标化合物相符。

Abstract:

Using inexpensive and readily available m-hydroxybenzaldehyde, primary amine and dimethyl carbonate, ortho-anisicaldehyde was synthesized by simple condensation, nucleophilic substitution and hydrolysis reactions under moderate condition. Through screen experiments, excellent synthetic condition which is ortho-hydroxy-benzylidene-butylamine/DMSO/KOH/85oC/24h was established. Comparing to reported methods in 60%-70% yields , the good yield was achieved up to 81% and the method is environmentally friendly. The product was characterized through 1H NMR, 13C NMR spectra and elemental analysis.