1,2-二甲基-4-叔丁基苯的合成

Synthesis of 1,2-dimethyl-4-tert-butylbenzene

摘要:

以氧化铁为催化剂，叔丁基氯和邻二甲苯为原料合成了1,2-二甲基-4-叔丁基苯。反应过程不用添加溶剂，没有废液产生，对环境更为友好。探讨了反应温度、反应时间、叔丁基氯和邻二甲苯摩尔比、催化剂用量等因素对反应的影响。结果表明：反应温度50 ℃，反应2.5 h，以氧化铁为催化剂，1,2-二甲基-4-叔丁基苯收率97.77 ％，选择性为99.48 ％。纯度为99.3 ％（经气相色谱测定）的产物，经核磁（1H NMR）表征确定。

Abstract:

Catalysted by Fe2O3,The synthesis of 1,2-dimethyl-4-tert-butylbenzene was performed with tert-butyl chloride and o-xylene .This new method is friendly to environment,because we didnot use any solvent and the reaction is simply compeleted without any wasts.Then,we studied the essential factors that maybe influence reaction,for example,temperature,time,mole ratio of tert-butylchloride to o-xylene,the amount of catalyst and etc.The results show that at 50 ℃,catalysted by Fe2O3,we can get the target product in 2.5 hours,A catalyst of Fe2O3 ensuring production of 1,2-dimethyl-4-tert-butylbenzene with a 97.77 % yield and selectivity of o-xylene conversion to the target product of 99.48 % was developed。The product of 99.3 % purity（by Gas chromatogram） is confirmed by 1HNMR.