3-（2-（1，3-二噁烷-2-基）-6-甲氧基）苯氧基苯甲醛的合成

Synthesis of 3-(2-(1, 3-dioxane-2-yl)-6-methoxy) phenoxyl benzaldehyde

摘要:

以2-羟基-3-甲氧基苯甲醛（Ⅰ）为原料经醛保护合成2-（1，3-二噁烷-2-基）-6-甲氧基苯酚（Ⅲ），化合物Ⅲ与3-溴苯甲醛（Ⅳ）经缩合反应，合成3-（2-（1，3-二噁烷-2-基）-6-甲氧基）苯氧基苯甲醛（Ⅴ）。采用1H NMR和MS对目标化合物Ⅴ进行结构表征。通过考察缩合反应的反应条件，得出合成化合物Ⅴ的最佳反应条件为：n(Ⅲ) : n(Ⅳ) : n(K2CO3) : n(CuCl)=1: 1.05: 2: 0.3，在回流条件下反应时间为5 h，产率为68.8%，纯度为98.7%。

Abstract:

2-(1,3-Dioxane-2-yl)-6-methoxyphenol (Ⅲ) was synthesized by 2-hydroxy-3-methoxy benzaldehyde (Ⅰ) with acetalation. 3-(2- (1, 3-Dioxane-2–yl)-6-methoxy) phenoxyl benzaldehyde (Ⅴ) was synthesized by reaction of compounds Ⅲ and 3-bromobenzaldehyde (Ⅳ). Structure characterization of the target compound Ⅴ was made based on 1H-NMR and MS. By changing reaction condition, the optimum reaction conditions for compounds Ⅴ were found as follows: n(Ⅲ): n(Ⅳ): n(K2CO3): n(CuCl) = 1: 1.05: 2: 0.3. Reaction time and yield was 5h and 68.8% respectively under reflux condition, the purity was 98.7％.