辅酶Q10纳米结构脂质载体的制备和表征

Preparation And Characterization of CoQ10-Loaded Nanostructured Lipid Carriers

摘要:

通过高压均质法制备运载辅酶Q10的纳米结构脂质载体（CoQ10-NLC），并对制备工艺条件进行优化；测定其粒径、分散度、Zeta电位和保留率；模拟考察CoQ10-NLC的皮肤吸收效果。实验结果表明，制备得到的CoQ10-NLC分散液粒径分布均一，物理稳定性高，低温4℃贮藏条件下CoQ10保留率高达80%；体外透皮实验表明，CoQ10-NLC能够增加CoQ10在表皮和真皮中的渗透量。

Abstract:

Abstract: The aim of this research was to prepare the CoQ10-loaded nanostructured lipid carriers by high pressure homogenization method. The optimized CoQ10-NLC was assessed for particle size、polydispersity index、Zeta potential、retention rate and in vitro permeation in pig skin. The results showed that CoQ10-NLC had good dispersing and high physical stability. Especially, after a month the retention rate of CoQ10 was higher than 80% at the storage condition of 4 ℃ . In vitro transdermal study indicated CoQ10-NLC enhanced the permeation of CoQ10 in the viable epidermis and dermis.