空气氧化一锅法合成1,2,3,4-四氢吲哚[2,3-b]喹喔啉

One pot synthesis of 1,2,3,4-tetrahydro-6H-indolo[2,3-b]quinoxaline via air oxidation

摘要:

为了探索喹喔啉新的合成路线，以吲哚醌和环己二胺为原料在空气中氧气的作用下合成了1,2,3,4-四氢吲哚[2,3-b]喹喔啉，共合成衍生物12个，所合成的化合物通过红外、核磁、质谱进行了表征，化合物9-氟-1,4-二氢吲哚喹喔啉（Ⅰl ）和9-甲基-1,4-二氢吲哚喹喔啉（Ⅰm ）进行了X衍射分析。结果表明合成了目标结构的产物。

Abstract:

In order to explore the new synthetic route of quinoxaline，1, 2, 3, 4-Tetrahydro-6H-indolo [2,3-b]quinoxaline was synthesized from Ortho-diaminocyclohexane and isatins by air oxidation.12 compounds were synthesized and their structures were confirmed by IR, 1HNMR and MS. Compound 9-fluoro-1,4-dihydro-1H-indolo[2,3-b]quinoxaline (Ⅰl ) and 9-methyl-1,4-dihydro-1H-indolo[2,3-b] quinoxaline (Ⅰm ) use X-ray diffraction analysis. The results showed that the target structures products were obtained.