Salen Mn(III)/NBS催化次氯酸钠氧化4,4’-二羟基二环己烷合成4,4’-二环己酮

Synthesis of Bicyclohexyl-4,4'-dione from The Oxidation of Bicyclohexyl-4,4'-diol with Sodium Hypochlorite Catalyzed by Salen Mn(III)/NBS

摘要:

以Salen-Mn(III)为催化剂、NBS为溴源构建了一种催化体系，以次氯酸钠为氧化剂成功地将4,4'-二羟基二环己烷氧化为4,4'-二环己酮。分别考察了催化剂Salen Mn(III)、NBS以及次氯酸钠用量对反应的影响，发现当4,4'-二羟基二环己烷为0.5 mmol、Salen-Mn(III) 0.04 mmol、NBS 0.26 mmol、次氯酸钠18 mmol时，在25 ℃反应0.5 h时，4,4'-二羟基二环己烷的转化率和4,4'-二环己酮的选择性分别高达96.1%和93.0%。

Abstract:

Bicyclohexyl-4,4’-dione was successfully synthesized by Salen Mn(III) catalyzed oxidation of bicyclohexyl-4,4'-diol using sodium hypochlorite as an oxidant and NBS as bromine source. The parameters including the Salen Mn(III) dosage, NBS dosage and sodium hypochlorite dosage were investigated. It was found that bicyclohexyl-4,4'-diol achieved a conversion of 96.1% and the selectivity of bicyclohexyl-4,4'-dione reached up to 93.0% under the optimum conditions: bicyclohexyl-4,4'-diol dosage 0.5 mmol, Salen-Mn(III) dosage 0.04 mmol, NBS dosage 0.26 mmol , sodium hypochlorite dosage 18 mmol, reaction temperature 25 ℃, and reaction time 0.5 h.