DMAc促进取代肉桂酰吗啉的合成

Dimethylacetamide-promoted Synthesis of Substituted Cinnamyl Morpholine

摘要:

以N,N-二甲基乙酰胺（DMAc）为促进剂，取代肉桂酸（1a～1i）先与SOCl2在0 ℃下反应20 min，再与加入的吗啉在25 ℃下反应7 h，合成了一系列取代肉桂酰吗啉（2a～2i），产率81.6%～95.4%。其结构经1H NMR、13C NMR、IR和MS确证。提出了DMAc促进取代肉桂酰吗啉合成反应的机理。

Abstract:

A series of cinnamyl morpholine(2a～2i)were synthsized by the chlorination of substituted cinnamic acids(1a～1i)with thionyl chloride in DMAc at 0 ℃ for 20 min，followed by amidation in situ with morpholine at 25 ℃ for 7 h. The yield of 2a～2i were 81.6%～95.4%. The structures were characterized by 1H NMR、13C NMR、IR and MS. The proposed mechanism for the promotion of dimethylacetamid on the syntehsis was suggested.