壳聚糖季铵盐修饰的辅酶Q10纳米结构脂质载体的制备及表征

Preparation and Characterization of CoQ10-Loaded Nanostructured Lipid Carriers modified by Quaternized chitosan

摘要:

为了增强运载辅酶Q10的纳米结构脂质载体（CoQ10-NLC）的透皮效果，本研究采用促渗剂——壳聚糖季铵盐（QCS）对CoQ10-NLC进行表面修饰，并结合QCS分子链的自聚集行为，明确QCS-CoQ10-NLC的形成机制，得到粒径在500 nm左右的脂质载体。进一步通过体外透皮实验，考察了QCS-CoQ10-NLC的透皮吸收效果，结果显示经0.5%质量分数的QCS修饰后，脂质载体可显著增加CoQ10在皮肤中的渗透量。

Abstract:

In order to enhance the transdermal penetration of CoQ10-loaded nanostructured lipid carriers (CoQ10-NLC), penetration enhancer--quaternized chitosan (QCS) was used to modify the surface of CoQ10-NLC. The self-aggregation behavior of QCS molecular chain was also studied to illuminate the formation mechanism of QCS-CoQ10-NLC. And QCS-CoQ10-NLC with particle size around 500 nm were prepared. In addition, the transdermal penetration of QCS-CoQ10-NLC was investigated by in-vitro transdermal study, the result showed that lipid carriers modified by QCS at 0.5% (w/w) could obviously improve the transdermal penetration of CoQ10 in the skin.