光控释负载吲哚美辛的氧化锌载药微粒的制备与性能

Synthesis and Performance of Light-Controlled Release Indometacin Loaded ZnO Particles

摘要:

利用直接沉淀法制备出粒径分布在180 nm左右的氧化锌微粒，通过溶剂挥发法，负载吲哚美辛。结果表明，当氧化锌同吲哚美辛的质量比为1：1时，可获得最优吸附率74.00±1.11%。考察了有/无紫外光照射处理负载吲哚美辛的氧化锌载药微粒的药物释放行为，发现紫外光照射下吲哚美辛可大量释放，而无紫外光照射时吲哚美辛几乎不释放，说明该药物载体可实现光控释放。同时，利用MTT法检测一定浓度药物载体对角质形成细胞的活性的影响，结果显示，细胞活性率均高于78.64%，表明其生物相容性良好。

Abstract:

ZnO particles of which size was around 180 nm were synthesized by direct precipitation. Indometacin was adsorbed to those particles. The optimal adsorption rate reached up to 74.00±1.11% when the mass ratio was 1:1. The drug release behavior was controlled by the UV radiation, since indometacin largely released under UV radiation while hardly released without UV radiation. The cellular viability of HaCaT was above 78.64±1.24% in the experimental concentration range, showing the good biocompatibility of indometacin loaded ZnO particles.