用支撑液膜法构建三相体系提取洁霉素

Recovery of Lincomycin by Three-phases Liquid Membrane

摘要:

摘要：运用支撑液膜技术建立了进料相、膜相、反萃取相三相体系，实现了对洁霉素的分离提纯。该体系采用了洁霉素+异构烷烃（Isopar L）+HCl的反应体系，验证了进料浓度（Cb f）、进料相溶液pH、反萃取相溶液pH、萃取剂组成等因素对分配系数（D）的影响。同时，优化了膜组件实现萃取实验的操作条件，根据传质过程建立了数学模型。结果显示：当洁霉素进料浓度Cb f为11.9mmol/L、Isopar L体积分数VF为80%、进料相pH为10.1、反萃取相pH为1.2时，分配系数D最大为2.34。确定膜组件操作条件为：管程流量Vf=520mL/min，壳程流量Vs=500mL/min。根据所建的数学建模分析了各部分传质阻力，其中管程传质阻力为6.7×105s/m，壳程传质阻力为3.7×105s/m，跨膜传质阻力为2.7×106s/m，跨膜传质阻力为主要的传质阻力。

Abstract:

Abstracts: This paper built a three-phases system composing of the feed phase, the membrane phase and the stripping phase using supported liquid membrane technique, which made the separation of lincomycin from aqueous solutions come true. The system of lincomycin+isoparaffin(Isopar L) in kerosene+HCl was used. The effects of initial lincomycin concentration (Cb f) in the feed phase, the pH of the feed phase, the pH of the stripping phase and the extraction solvent volume fraction (VF) on the distribution coefficient (D) were studied. Besides, we optimized the operating conditions of membrane module to realize the extraction. We also established a mathematical model to analysis the mass transfer process and the resistance of the process. The results show that the maximum distribution coefficient D=2.34 can be obtained with 11.9 mmol/L of lincomycin, 80% Isopar L(volume fraction) in the extractant, pH=10.1 in the feed phase and pH=1.2 in the stripping phase. The optimum operating conditions of membrane module is 520:500 (mL/min) of tube side flow rate Vf and shell side flow rate Vs. Mass transfer resistances were analyzed, the tube-side resistance is 6.7×105s/m, the shell-side resistance is 3.7×105s/m and the membrane-phase resistance is 2.7×106s/m，showing the resistance from the extraction reaction to be dominant.