香豆素肟酯类化合物的合成

Synthesis of Coumarin Oxime Ester Compounds

摘要:

以取代的3-乙酰基/丁酰基香豆素为原料，通过两步合成了一系列香豆素肟酯类化合物。以化合物3a的合成为模板反应，考察了溶剂的种类和反应温度对产物产率的影响，结果表明以四氢呋喃为溶剂、反应温度为60℃时产物的产率最高。在最优条件下，以 67% ～92% 的收率得到 11 种含不同取代基的香豆素肟酯类化合物。目标化合物的结构进行了红外、核磁和X-射线单晶衍射表征确认。

Abstract:

A series of coumarin oxime esters were synthesized by two-step reaction with substituted 3-acetyl/butyryl coumarins as the raw material. The reaction of compound 3a was carried out as template reaction, and the effects of the solvent and temperature on the yield of 3a was investigated. The results showed that the yield of the product was the highest when the reaction temperature was 60 ℃ with tetrahydrofuran as solvent. Eleven coumarin oxime esters with different substituent groups were synthesized in 67% ～ 92% yields under the above-mentioned reaction conditions. The struxtures of target compounds have been confirmed by IR, NMR and X-ray crystal diffraction.