星点设计-效应面法优化右旋布洛芬/酸改性蒙脱土干混悬剂的制备工艺

Optimization of Preparation of S( )-ibuprofen/Acid-Montmorillonite Dry Suspension by Composite Design-response Surface Method

摘要:

通过星点设计-效应面法优化右旋布洛芬/酸改性蒙脱土（S( )-IBU/acid-MMT）干混悬剂的制备工艺。以蒙脱土的比表面积和孔容为考察指标，采用3因素5水平星点设计考察盐酸浓度、反应时间、反应温度对干混悬剂制备工艺的影响，并对结果进行二元多项式线性回归方程拟合，经效应面法预测最佳处方；借助现代分析技术对干混悬剂进行结构表征。右旋布洛芬/酸改性蒙脱土干混悬剂最佳条件为：盐酸浓度3.3 mol/L，反应时间5.5 h，温度55 ℃，酸改性的MMT比表面积达318.8 m2/g，孔容0.51 cm3/g，载药量最高可达460.8 mg/g。星点设计-效应面法适用于右旋布洛芬/酸改性蒙脱土干混悬剂制备工艺优化，以此方法建立的数学模型具有良好的预测性，所得干混悬剂具有更高的载药量。

Abstract:

To optimize the formulation of S( )-IBU/acid-MMT dry suspension by the central composites design-response surface methodology. Using surface area and pore volume as indexes, the influence of hydrochloric acid concentration; reaction time and temperture was investigated by central composite design-response surface method. The results were fitted by second-order polynomial equation, and the optimal preparation technology was predicted according to formulation. The quality of S( )-IBU/acid-MMT composites were characterizedby powder XRD and SEM. Central composite design finalized prescription is 3.3 mol/L, 5.5 h, 55 ℃, its BET surface area and pore volume is 318 m2/g, 0.51 cm3/g, respectively.The acid-MMT loading capacity 460.8 mg/g. Using the central composite design-response surface method to optimize the preparation of S( )-IBU/acid-MMT dry suspension has a good prediction S( )-IBU/acid-MMT dry suspension showsmore capacity by central composites design.