响应面法优化微波辐射合成甲基丙烯酸异冰片酯

Using Response Surface Methodology to Optimize Microwave Irradiation for Synthesis of Isobornyl Methacrylate

摘要:

以莰烯和甲基丙烯酸为原料，采用微波辐射法合成了甲基丙烯酸异冰片酯（IBOMA）。在微波反应时间、反应温度、微波功率、莰烯与甲基丙烯酸的物质的量之比及催化剂用量等单因素试验基础上，通过Design Expert8.0中的中心响应面法对反应条件进行了优化，确定最佳合成工艺为：催化剂用量为10%、烯酸物质的量之比为1:0.8、微波反应时间25min、反应温度43℃、功率为400W。在此工艺条件下，IBOMA的酯收率可达到82.23%。

Abstract:

Isobornyl methacrylate (IBOMA) was synthesized by microwave irradiation using camphene and methacrylic acid as raw materials. The reaction conditions were optimized by Design Expert 8.0, based on the single factor experiments of the reaction time, microwave temperature, microwave power, molar ratio of camphene and methacrylic acid and catalyst dose. These variables were optimized by Central Composite experimental design in combination with response surface analysis . The results showed that the optimal conditions were as follows : reaction temperature 43℃ , n(camphene)/n(Methacrylic acid)=1:0.8 , catalyst dose 10% , irradiation time 25min and microwave power 400W . Under the optimal conditions,the esterification rate can reach 82.23% .