金属有机骨架材料Fe3O4@ZIF-8作为药物载体的研究

Study on metal organic skeleton Fe3O4 @ ZIF-8 as drug carrier

摘要:

磁性金属有机骨架材料具有能够增加药物靶向性的特点。本实验在以往实验的基础上，制备新的MOFs材料，以FeCl3?6H2O、乙酸钠、Zn（NO3)2?6H2O、2-甲基咪唑作为主要原料，通过水热法合成Fe3O4@ZIF-8磁性金属有机骨架材料。对材料进行表征。以材料作为药物载体，负载药物四环素，以负载量作为主要评价指标，结果显示：在PH=9、材料用量5mg、药物浓度30mg/L的条件下饱和负载量达到12.296mg/g。

Abstract:

Magnetic metal organic skeleton materials have the characteristics of ability to increase drug targeting. Based on the previous experiments, Fe3O4@ZIF-8 was prepared by hydrothermal method using FeCl3?6H2O, sodium acetate, Zn（NO3)2?6H2O and 2-methylimidazole as the main raw materials. Magnetic metal organic skeleton material. The materials were characterized . The material was used as the drug carrier and the loaded drug tetracycline was used as the main evaluation index and detected by UV spectrophotometer. The results showed that the saturated loading reached 12.296mg / g under the conditions of pH = 9, material dosage 5mg and drug concentration 30mg / L.