α-糜蛋白酶催化合成二吡咯甲烷衍生物

Synthesis of Dipyrromethanes Catalyzed by α-Chymotrypsin

摘要:

以α-糜蛋白酶为生物催化剂，以40%乙醇水溶液为反应介质，50℃条件下，通过吡咯与醛的串联反应，合成了一系列二吡咯甲烷衍生物。该方法条件比较温和、反应时间较短，底物范围较宽泛，也无需氮气保护，该研究进一步拓展了酶的非专一性及α-糜蛋白酶在有机合成中的应用。

Abstract:

A series of dipyrromethanes was synthesized by the tandem reaction of pyrrole and aldehyde in 40% alcohol solution at 50 oC using α-chymotrypsin as biocatalyst. This method have the merits of mild reaction conditions, shorter reaction time, broad substrate scope and no need of nitrogen protection. The results further expand the application of enzyme’s promiscuity and α-chymotrypsin in the organic synthesis.