染料木素的结构修饰及活性研究进展

Progress in Structure Modification and Activity of Genistein

摘要:

染料木素是大豆异黄酮的主要活性成分，其具有抗癌，抑菌，降血脂等多种药理作用；但其存在着水溶脂溶性差、首过效应明显、特异性差、生物利用度低等不足。因此对染料木素进行结构修饰以提高其生物活性、改善生物利用度、发现新活性是当前研究的重点，同时也取得了重要进展。本文主要对染料木素结构修饰及活性方面的研究进展进行综述。

Abstract:

Genistein is the main active ingredient of soy isoflavones，which possesses many pharmacological effects such as anticancer，antibacterial and hypolipidemic. However it has the disadvantages of poor water solubility，poor lipid solubility，poor specificity，strong first pass effect and low bioavailability. The progress in improving its biological activity，bioavailability， and new activity by the structural modification of genistein has been made. In this paper，the progress of modification and activity of genistein was reviewed.