4A沸石对海藻酸钠壳聚糖复合微球性能的影响

Effect of 4A Zeolite on The Properties of Sodium Alginate / Chitosan Composite Microspheres

摘要:

以壳聚糖和海藻酸钠为原料，4A沸石为结构改良剂，采用复凝聚法制备4A沸石/海藻酸钠/壳聚糖复合微球，利用显微镜、扫描电镜、红外光谱和X射线衍射等对复合微球进行了表征，并考察了4A沸石对复合微球成球性能和溶胀性能的影响。结果表明，随着4A沸石添加量的增加复合微球的质量和粒径也增大，添加4A沸石有利于复合微球成球，成球率最高达到98.5%，且冷冻干燥后粒径均匀、球形规则。在不同pH和温度条件下，4A沸石对复合微球能有效抑制微球的大量溶胀，同时保持良好的pH和温度敏感性。4A沸石可以作为药物控释体系中的结构改良剂进一步研究应用。

Abstract:

Using chitosan and sodium alginate as raw material and 4A zeolite as structural modifier, 4A zeolite/sodium alginate/chitosan composite microspheres were prepared by complex condensation, the composite microspheres were characterized by means of microscope、SEM 、XRD and FTIR. The effect of 4A zeolite on microsphere formation and swelling properties of the composite microspheres was investigated. The results show that the weight and particle size of the composite microspheres increased with the increase of the 4A zeolite addition. 4A zeolite was beneficial to the granulation of Composite Microspheres, The highest rate of granulation reached 98.5%. After freeze-drying, the particle size were uniform, and the sphericity was regulation. Under different pH and temperature conditions, 4A zeolite can effective inhibits the swelling performance of composite microspheres, but the microspheres still maintained pH and temperature sensitivity. 4A zeolite can be used as a structural modifier in drug controlled release system for further research and application.