磷酸型化合物设计合成方法研究进展

Research Advance in Design and Synthesis Methods of Compounds Based on Phosphoric Acid

摘要:

磷元素在物质与能量转化过程中的广泛参与及生命科学中的重要作用，被誉为“生命活动的调控中心”。在生命活动的重要性与磷化合物的生物相容性以及界面友好性，并具有良好的抗病毒、抗癌、除草活性和良好的洗涤、乳化、分散以及抗静电性能，吸引着许多科学家在磷酸型化合物设计、合成与性能方面开展了大量的、深入的和系统的研究工作。在近年来研究工作的基础上，较为系统地综述了设计合成含磷化合物的Kabachnik-Fields反应、Atherton-Todd反应、Abramov反应、Michaels加成反应和偶联反应及相应的反应机理，对含磷化合物在生命科学、医药卫生、航空航天和三次采油等应用领域与发展趋势进行了展望。

Abstract:

Phosphorus is widely involved in the conversion of substances and energy in biochemical reactions and plays an important role in life sciences. It is regarded as the "regulatory center of life sciences". Many scientists have carried out deep and systematic studies in the design, synthesis and properties of phosphoric acid compounds due to the importance of phosphorus in life activities and the biocompatibility and interfacial friendliness of phosphorus compounds. On the basis of recent researches on phosphate compounds, especially phosphoric acid compounds, the present situation and progress in the design, synthesis and basic application of phosphoric acid compounds are reviewed in this paper. For phosphorus-based compounds, especially phosphate compounds, based on the research work in recent years, this article systematically reviews the current status and progress of design synthesis and basic application research of phosphate-type compounds. The Kabachnik-Fields reaction, Atherton-Todd reaction, Abramov reaction, Michaels addition reaction and coupling reaction involving the design and synthesis of phosphorus-containing target compounds were highlighted. The application field and development trend of phosphorous compounds based on the above reaction design and synthesis are also prospected.