双氧水氧化乙二醛合成乙醛酸的连续流工艺

Study on Continuous Flow Synthesis Process of Glyoxylic Acid by Oxidation of Glyoxal with Hydrogen Peroxide

摘要:

以乙二醛和双氧水为原料，在微通道反应器中考察了液相氧化合成乙醛酸的连续流工艺。考察了物料比、催化剂用量、双氧水浓度、停留时间、温度等对反应的影响。确定该法最佳工艺条件为，n(乙二醛)∶n(H2O2)∶n (FeSO4)= 1∶1∶0.13，双氧水浓度1.67 mol/L，停留时间10min，反应温度30℃。在该条件下，乙二醛转化率达到94.7%，乙醛酸选择性达到85.4%。此工艺充分利用微通道反应器优良的传质传热特点，大大缩短了反应时间，提高了反应速率，扩大了工艺条件选择区间，实现了对氧化反应过程的有效控制，增加了安全系数。

Abstract:

The continuous flow process of liquid phase oxidation to glyoxylic acid was studied in a microchannel reactor using glyoxal and hydrogen peroxide as raw materials.The effects of material ratio, catalyst dosage, hydrogen peroxide concentration, residence time and temperature on the reaction were investigated.The optimized reaction conditions are: n(glyoxal)∶n(H2O2)∶n(FeSO4)= 1∶1∶0.13, the hydrogen peroxide concentration 1.67 mol/L, residence time 10 min, and reaction temperature 30℃. Under the above-mentioned reaction conditions, glyoxal conversion rate reaches94.7%and the glyoxylic acid selectivity reaches 85.4%.This process takes full advantage of the excellent mass and heat transfer characteristics of the microchannel continuous flow reactor, greatly shortens the reaction time, increases the reaction rate, expands the selection range of the process conditions, realizes the effective control of the oxidation reaction process, and increases the safety factor.