l-薄荷醇的合成工艺研究

The synthesis of l-menthol

摘要:

文章阐述了d-香茅醛催化合成l-薄荷醇的工艺研究，通过考察反应温度、反应时间、催化剂用量、催化剂位阻四个方面筛选出最优反应条件。最佳的工艺条件：甲苯为溶剂，d-香茅醛为起始原料，以铝原子为中心，三苯基苯酚为配体的催化剂用量为1% (摩尔比)，反应温度0oC以下，反应时间3h，减压蒸馏得到中间产物后加氢还原得到l-薄荷醇，总收率76%，GC纯度99%以上。

Abstract:

L-menthol was synthesized by using d-citronellal as raw material.The optimal reaction conditions were selected by investigating the reaction temperature, reaction time, catalyst dosage and catalyst steric hindrance. The results showed that the optimal reaction conditions were that toluene as solvent, d-citronellal as starting material, aluminum atom as the center, triphenylphenol as ligand, the amount of catalyst was 1% (mole fraction), reaction temperature was 0 ℃，the reaction time was 3 h, and an intermediate product was obtained by distillation under reduced pressure, followed by hydrogenation reduction to obtain 1-menthol, the total yield was 76%, and the GC purity was above 99%.