基于pH敏感型葡聚糖水凝胶微球的药物载体

Synthesis and characterizations of pH-sensitive dextran nanogel as drug delivery system

摘要:

以葡聚糖为原料，采用反相微乳液技术制备了一种含有席夫碱结构的葡聚糖基水凝胶纳米微球作为载体，通过交联剂聚乙烯亚胺（PEI）的静电吸附作用对药物模型8-羟基芘-1,3,6-三磺酸三钠盐（HPTS）进行了包埋，利用FTIR、SEM和DLS等对微球的结构和形貌进行了表征。结果表明这种葡聚糖纳米水凝胶载药前后均具有良好的球形结构，粒径分布在459~648 nm。载药效果及药物释放行为研究发现：该葡聚糖纳米水凝胶可对HPTS进行有效负载，且其释放行为具有明显的酸性环境敏感性，酸性越强，释放越快。含有席夫碱结构的葡聚糖纳米凝胶微球可作为pH敏感型载体应用于药物递送领域。

Abstract:

Dextran-based nanogel with Schiff base structure were prepared by the inverse microemulsion technique, and its functions as drug carrier was studied using HPTS as model drug, which was loaded via the electrostatic adsorption with polyethyleneimine (PEI, crosslinker). The structure of dextran nanogel was characterized by FTIR、SEM and DLS. The dextran nano-hydrogel has a good spherical structure before and after drug loading, and the particle size is mainly distributed at about 459~648 nm. HPTS can be effectively loaded into the dextran nanogel and showed an obvious acidic environment sensitive release behavior. The stronger the acidity, the faster the drug released. The dextran nanogel with Schiff base structure can be used as a pH-sensitive drug delivery system.