3D打印技术用于不规则骨缺损的重建与修复

D printing technology for reconstruction and repair of irregular shaped bone defects

摘要:

为研究3D打印技术对不规则形状骨缺损模型的重建程度，和3D打印的可降解生物材料对脊椎骨缺损在12周内的修复的效果，本文随机选取一名病人，用其电子计算机断层扫描（computed tomography, CT）数据构建出不规则的三维脊柱缺损模型，选用聚己内酯（polycaprolactone, PCL）作为支架材料，运用3D打印技术打印出高度符合该病人骨缺损部位的人工骨支架。同时建立一个简单的兔子脊椎缺损模型，运用3D打印技术打印缺损尺寸的支架移植兔子体内，术后观察3个月，将兔子处死取出缺损部位，制作切片进行苏木素和伊红（Hematoxylin and Eosin, H&E）染色，染色结果表明缺损部位修复良好。

Abstract:

In order to study the degree of reconstruction of irregularly shaped bone defect models using 3D printing technology and the effect of 3D printed degradable biomaterials on the repair of vertebral bone defects in three months. Biodegradable biomaterials, polycaprolactone (PCL) were used as the printing ink to print scaffold materials for repair. An irregular three-dimensional spine defect model was constructed using CT data from a randomly chosen patient. An artificial bone scaffold with a height that matches the patient's bone defect was first printed using 3D printing. At the same time, a rabbit spinal defect model was established, and a defect-sized stent was transplanted into the rabbit using 3D printing technology. The defect was removed from the rabbit after 3 months of surgery and sections of the defect area were made for Hematoxylin and Eosin (H&E) staining. The repair indicated that 3D printed bone scaffold has a promising application on the treatment of irregular bone defects formed during spinal surgery.