2,3-双八氟戊烷基甘油醚-1-硫酸酯钠的合成及表面性能

Synthesis and surface properties of sodium 2,3-bis-octafluoropentanylglycerol-1-sulfate

摘要:

以八氟戊醇（HCF2CF2CF2CF2CH2OH）和2, 3-二溴丙醇为原料，设计并合成了甘油醚类氟碳表面活性剂（2,3-双八氟戊烷基甘油醚-1-硫酸酯钠，BOFPGS），通过FTIR、NMR以及MS等对中间产物（2,3-双八氟戊烷基-1-丙醇）和最终产物（BOFPGS）进行了结构表征。对BOFPGS进行了表面张力测试，结果表明，BOFPGS的临界胶束浓度（CMC）为4.16 × 10-3mol/L，CMC对应的表面张力为22.70 mN/m。将不同浓度的BOFPGS水溶液和相同体积的液体石蜡乳化后，析水率随着时间延长而增大，乳液在乳化30 min时趋于稳定。BOFPGS浓度低至0.8 × 10-3 mol/L时，其仍具有较好的乳化性能。利用噻唑蓝（MTT）法对该表面活性剂的细胞毒性进行测试，结果表明，BOFPGS在8.04 × 10-6 ~ 1.60 × 10-4 mol/L内无明显细胞毒性。

Abstract:

In this study, a novel glyceryl ether fluorocarbon surfactant（sodium 2, 3-bis-octafluoropentanylglycerol-1-sulfate, BOFPGS） was synthesized through a two-step reaction by using 1H, 1H, 5H-octafluoropentanol and 2,3-dibromopropan-1-ol. The structures of intermediate and product were characterized by Fourier-Transform Infrared spectroscopy（FTIR）, 1H NMR spectroscopy and mass spectrometry（MS）. The surface activity was measured. The results showed that it had good surface tension（22.70 mN/m） and critical micelle concentration（4.16 x 10-3mol/）. In addition, emulsifying experiments demonstrated that BOFPGS possessed excellent emulsifying properties at a low concentration of 0.8 × 10-3 mol/L. Moreover, the cytotoxicity experiment verified that BOFPGS had no obvious cytotoxicity at the concentration range of 8.04 × 10-6~ 1.60 × 10-4 mol/L.