表面活性剂蔗糖酯在药物递送系统的应用

Application of sucrose esters in drug delivery system

摘要:

蔗糖酯（Sucrose esters，SEs）是一种被广泛使用在食品、化妆品工业中的表面活性剂。近年来，SEs由于其良好的生物降解性、乳化和增溶作用，在医药领域的应用是其应用的一个巨大突破，引起了国内外研究者的极大兴趣。SEs在药物控制释放体系中，能促进药物的溶解、药物的吸收或渗透，从而提高药物的治疗效果。目前，关于蔗糖酯在药物递送领域的应用还没有综述文献的报道，本文在近年来SEs用于药物递送研究的基础上，介绍了SEs的主要特性、其在生物医药领域的应用，着重讨论和总结了SEs在药物递送领域的一些应用，以及SEs的毒理学研究现状。展望了SEs在医药领域的发展前景，并提出SEs在该领域还需深入研究的问题，为SEs在医药领域的深入研究提供理论参考。

Abstract:

Sucrose esters (SEs) are surfactants that are widely used in the food and cosmetic industries. In recent years, the application of SEs in the field of medicine is a huge breakthrough due to its good biodegradability, emulsification and solubilization effects, which brings a great interest to the researchers of all over the world. SEs can promote the dissolution, absorption and penetration of the drug, thereby improving drug efficiency and reducing its side effect. There is little review report on the application of sucrose esters in the field of drug delivery. In this paper, the main characteristics of SEs and the recent research progress in their applications in the field of biomedicine are reviewed, some applications of SEs in drug delivery and toxicology research are discussed and summarized. The future opportunities and challenges on the application of SEs in the field of medicine are prospected. The review will provide reference and theoretical support for the further study and clinical application of SEs.