醛-亚胺-壳聚糖水凝胶的构筑及性能研究进展

Research progress in construction and property of aldehyde -imine- chitosan hydrogel

摘要:

动态亚胺键（又称席夫碱键）具有pH响应性、可逆性和生物活性等，因此，亚胺键交联构筑的水凝胶可能被赋予许多新的功能。壳聚糖是自然界中唯一的碱性多糖，分子链上丰富的氨基为醛-亚胺-壳聚糖（CSB）水凝胶的构筑提供了可能。近年来，CSB水凝胶的构筑和应用受到关注，其中，醛类交联分子的结构和交联点的设计成为研究热点之一。该文按照醛类交联分子的结构特点，对CSB水凝胶的构筑方法、机理以及自愈合性能、药物缓释性能、抗菌性能、荧光性能和导电性能等进行了综述，为构筑多功能壳聚糖水凝胶提供理论指导。设计合成生物相容性好、多功能醛类交联剂；提高CSB水凝胶的力学性能、自愈合性能和刺激响应性能，是CSB水凝胶的重要研究方向。

Abstract:

The dynamic imine bond (Schiff base bond) shows good pH responsiveness, reversibility and biological activity. Therefore, the hydrogel fabricated by the imine cross-linkages could be endowed with many new functions. Chitosan is the only alkaline polysaccharide in nature, and the abundant amino groups in the molecular chain provide the possibility of the construction of aldehyde-imine-chitosan (CSB) hydrogel. In recent years, the construction and application of CSB hydrogel have attracted wide attention, and the aldehyde cross-linking molecular structure and the design of cross-linking point have become one of research hotspots. According to the molecular structure of aldehyde crosslinker, the construction method and mechanism of CSB hydrogel, and its properties such as self-healing, drug sustained release, antibacteria, fluorescence and conductivity so on were reviewed in this paper, which could provide theoretical guidance for constructing multifunctional CSB hydrogel. It is important to design and synthetize biocompatible, multifunctional aldehyde crosslinker and improve mechanical property, self-healing ability and stimuli-responsiveness of CSB hydrogel.