高安全富勒烯化妆品原料及其美白、抗炎，修复功效

High safety fullerene cosmetic raw materials and their whitening, anti-inflammatory and repairing effects

摘要:

制备了两种水溶性富勒烯衍生物〔富勒烯透明质酸钠（MHAF60）、富勒烯聚乙烯吡咯烷酮(PPF60)〕，并对其护肤性能进行了测试。UV-Vis和FTIR结果显示，富勒烯依然保持了其特征吸收。DLS结果显示两种材料粒径分别为368.5nm和500.6nm。GC结果表明两种材料均无有机溶剂残留。EPR结果显示MHAF60淬灭自由基的能力要显著优于PPF60、维生素C和水溶性虾青素。以人表皮角质细胞（HEK-A）作为研究对象，测试了在双氧水损伤条件下MHAF60对细胞的修复和保护作用，结果显示MHAF60的效果显著优于维生素C和水溶性虾青素。斑马鱼模型试验结果显示MHAF60具有显著的抑制黑色素、抗炎修复功效，安全性更高。

Abstract:

Two kinds of water-soluble fullerenes〔fullerene sodium hyalornate（MHAF60 and fullenene polyvinylpyrrolidone (PPF60)〕were prepared and tested for skin care .The results of GC UV-Vis and FTIR showed that fullerenes still keep their characteristic absorption .The results of DLS showed that the particle sizes of the two materials are 368.5nm and 500.6nm, respectively The results of GC showed that there was no residual organic solvent in the two materials. EPR detection showed that the free radical quenching ability of MHAF60 was significantly better than that of PPF60, vitamin C and water-soluble astaxanthin. HEK-A cells was used to test the ability of fullerene to repair oxidative damage. The results show that MHAF60 has significant protective and repairing effects on cell injury, and the effect was significantly better than that of vitamin C and water-soluble astaxanthin. The results of zebrafish experiment showed that fullerene could significantly inhibit melanin production, inhibit inflammation and promote wound healing, and higher security.