周期性介孔有机硅的合成及在生物医药领域的应用进展

Synthesis and biomedicine applications of periodic mesoporous organosilicas

摘要:

周期性介孔有机硅（Periodic Mesoporous Organosilicas, PMOs）代表了一类桥联型有机-无机杂化介孔材料，它是在结构导向剂存在的条件下，由倍半硅氧烷作为前驱体通过溶胶-凝胶法自组装制备得到的新型介孔材料。通过桥联不同的有机基团，可以改变材料的理化性质，得到具有孔径可调、比表面积高、生物相容性好、细胞毒性低、水热稳定性好、表面和内部容易修饰等优点的介孔载体材料，被广泛应用于药物和基因的传递、肿瘤细胞的靶向及成像、药物的刺激性响应释放等许多方面。该文综述了PMOs的制备方法、类型、特点，并对其在生物医药领域的应用进行了总结，以期为PMOs的合成以及在生物医药领域的应用提供参考。

Abstract:

Periodic mesoporous organosilicas (PMOs) represents a class of bridging organic-inorganic hybrid mesoporous materials, which are prepared by sol-gel self-assembly of sesquisiloxane as precursor in the presence of structural directing agent. By bridging different organic groups, the physical and chemical properties of the materials can be changed to obtain mesoporous carrier materials with adjustable pore size, high specific surface area, good biocompatibility, low cytotoxicity, good hydrothermal stability, and easy surface and internal modification. PMOs are widely used in drug and gene delivery, tumor cell targeting and imaging, and drug irritant response release, etc. This paper reviewed the preparation methods, types and characteristics of PMOs, and summarized their application in biomedicine, in order to provide reference for the synthesis of PMOs and their application in biomedicine.