载体对甲维盐固体纳米制剂的性能影响

Effect of carrier on performance foremamectin benzoate solid nanoformulations

摘要:

为了研究载体对农药固体纳米制剂理化性能的影响及其选择原则，采用自乳化-载体固化法制备了7种不同载体的甲氨基阿维菌素苯甲酸盐（甲维盐）固体纳米分散体。比较了载体粉末粒度、溶解度、比表面积及形貌间的差异性，揭示了不同载体对甲维盐固体纳米分散体粒径、分散度、界面电荷、pH、晶型及叶面润湿性的影响。结果表明，农药固体纳米分散体中载体的理化性质及结构对纳米制剂的粒度、分散性、界面性质及晶型具有显著影响。苯甲酸钠为甲维盐固体纳米分散体的优良载体，载药粒子的平均粒径为22 nm，PDI为0.358。

Abstract:

In order to study the influence of the carrier on the physical and chemical properties of pesticide solid nanoformulations and its selection principles, the emamectin benzoate solid nanodispersions with seven different carries were prepared by self-emulsifying and solidification technology. The powder size, solubility, specific surface area and morphology of the carriers were compared. Furthermore, the effects of the carriers on the particle size, dispersibility, interfacial charge, pH, crystallinity and foliar wettability of the solid nanodispersions were revealed.The physicochemical properties and structures of the carriers have a significant impact on the particle size, dispersibility, interfacial property and crystallinity of the solid nanodispersion.Sodium benzoate and sodium butyrate were excellent carriers for emamectin benzoate solid nanodispersions. The particle sizes of the solid nanodispersions with sodium benzoate as carriers was 22 nm and the PDI was 0.358.