亚砜配体在金属催化烯丙基官能团化反应中的应用

Development of Sulfoxide Ligand for Allylic Functionalization

摘要:

过渡金属催化的烯丙基官能团化反应在有机合成中具有重要作用，是构建碳碳键和碳杂原子键的重要方法。亚砜配体以其独特的立体化学性质，不仅在传统的（Tsuji-Trost）烯丙基取代反应中取得优异结果，而且在烯丙基碳氢活化反应中展现出巨大潜力。本文根据产生烯丙基钯中间体的催化反应机理及亚砜配体配位模式的不同，总结了近些年亚砜配体在传统的烯丙基取代、烯丙基碳氢官能团化及不对称烯丙基碳氢官能团化领域的最新研究进展，指出影响各个催化体系的关键因素及所存的问题并对今后发展做出了展望。

Abstract:

Transition metal catalyzed allylic functionalization reaction plays an important role in organic synthesis, and is an important method to construct carbon-carbon bonds and carbon-heteroatom bonds. With its unique stereochemical properties, the sulfoxide ligand not only achieved excellent results in the traditional (Tsuji-Trost) allylic substitution reaction, but also showed great potential in the allylic C-H activition. According to the catalytic reaction mechanism of the allylic palladium intermediate and the coordination mode of the sulfoxide ligand, the research progress of sulfoxide ligands in the traditional allylic substitution, allylic C-H functionalization and asymmetric allylic C-H functionalization in recent years is summarized, points out the key factors and existing problems that affect each catalytic system and made a prospect for the future development.