热固化聚富马酸丙二醇酯/丙烯酸羟乙酯材料的制备与性能

Preparation and Properties of Thermo-cured Poly(propylene fumarate)/Hydroxyethyl Acrylate System Materials

摘要:

以富马酸二乙酯和1,2-丙二醇为原料，通过两步反应成功合成聚富马酸丙二醇酯（PPF），并以PPF、丙烯酸羟乙酯为单体，热固化构筑体系材料。利用FTIR）与1HNMR等手段对聚合物进行了表征，并测试了材料的热稳定性能、润湿性能、力学强度、体外细胞毒性及降解性能。结果表明，体系材料具有较好的热稳定性能，其中当PPF和丙烯酸羟乙酯质量比为1∶3时材料的热稳定性能较佳；材料的亲水性较好，其接触角为53.28 °～76.17 °；材料具有较好的力学性能，其剪切强度、粘接强度、压缩强度及三点弯曲强度分别为1.33～1.63 MPa、1.86～3.18 MPa、60.47～88.15 MPa、 18.77～20.63 MPa；体外降解实验结果表明，随着浸泡时间变长，体系溶液pH呈下降趋势，其变化值为0.093～0.628；当PPF和丙烯酸羟乙酯质量比为3∶1时，试样的失重率和吸水率分别可达11.20%和38.27%，材料的降解速率较为缓慢；细胞毒性实验结果显示体系材料细胞毒性轻微。

Abstract:

Using diethyl fumarate and 1,2-propanediol as the basic raw materials, poly(propylene fumarate) (PPF) was successfully synthesized through a two-step reaction, the PPFand hydroxyethyl acrylate were used as monomers to thermally solidify the system material.These polymerswerecharacterized by fouriertransformation infrared spectroscopy (FTIR) and hydrogen nuclear magnetic resonance spectroscopy (1H NMR). The thermal stability, wetting properties, mechanical strength, in vitro cytotoxicity and degradation properties of the materials were tested. These results showed that the system materials had good thermal stability, specially when the mass ratio of the PPF and hydroxyethyl acrylate was1∶3. The thermal stability, and hydrophilicityof the material was better with its contact angle being53.28°～76.17°; the material had good mechanical properties, its shear strength, adhesive strength, compressive strength and three-point bending strength were 1.33～1.63 MPa, 1.86～3.18 MPa, 60.47～88.15 MPa, 18.77～20.63 MPa, respectively; the results of in vitro degradation experimentsshowed that with the increase of soaking time, the pH of the system solution tends to decrease, and the valuechanges to 0.628 from 0.093.When the mass ratio of the PPF and hydroxyethyl acrylate was 3∶1, the weight loss rate and water absorption rate can reach 11.20% and 38.27%, respectively. Finally the degradation rate of the material was relatively slow and the cytotoxicity test results showed that the cytotoxicity of the system material was slight.