角蛋白基药物载体的发展及应用探讨

Development and application of keratin based drug carriers

摘要:

从毛发中提取角蛋白，开发具有独特功能的角蛋白基药物载体材料，提高药物的活性和生物利用率，既能够增加毛发的利用价值，又能够实现节能减排，符合可持续发展战略要求。对毛发中提取角蛋白进行二硫键重建、自由基聚合、多糖改性和烷基化等改性处理，赋予角蛋白基药物载体优异地功能特性，进一步拓宽其作为角蛋白基药物载体的应用范围。角蛋白基药物载体可被加工成纳米粒子、纤维支架、水凝胶等各种形式用于药物的递送。作为一种高硫含量且具有良好细胞相容性的结构蛋白，角蛋白基药物载体在组织工程、再生医学等领域扮演着重要的角色。

Abstract:

Keratin is extracted from cheap hair, and different forms of keratin-based drug carriers are developed to improve the activity and bioavailability of drugs, which not only increase the utility value of hair, but also realize energy conservation & emission reduction. So it meets with the stainable development strategy. Disulfide reconstruction, free radical polymerization, polysaccharide modification and alkylation of keratin can confer excellent functional properties to keratin-based carriers, in order to further widen its application scope as drug carriers. Keratin can be processed into nanoparticles, fiber scaffold, hydrogel and other forms for drug delivery. As a structural protein with high sulfur content and good cell compatibility, keratin-based drug carriers play a important role in tissue engineering, regenerative medicine and other fields.