二乙氨基羟苯甲酰基苯甲酸己酯结晶速率的影响因素

Study on Influencing Factors of Crystallization Rate of hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]-benzoate

摘要:

主要研究了当前使用最广泛的防晒剂二乙氨基羟苯甲酰基苯甲酸己酯（DHHB）在不同油脂中的溶解度变化，在所研究的七种油脂中发现分子结构中含有苯环数目较多的苯甲酸苯乙酯（226）油脂对DHHB防晒剂的相容性最大，超声溶解后常温25℃条件下放置28d时的溶解度为0.241 g/mL;以加热溶解和超声溶解两种方式, 考察了不同溶解方式对防晒剂重结晶的影响，发现加热溶解28d时的下降率比超声溶解的降低10%以上，其中在226油脂中溶解度下降率降低了高达35.67%，在TN油脂里下降率降低了12.65%；在不同储存温度（4℃、25℃）条件下防晒剂储存4周的溶解度变化，发现低温更容易促进防晒剂结晶。通过加入乳化剂司盘20、司盘80发现乳化剂的加入能明显减缓DHHB在油脂碳酸二辛酯（CC）中的溶解度下降率，加入司盘20后下降率降低了20.05%，加入司盘80后下降率降低了21.28%。通过观察防晒剂结晶行为，并对重结晶物质进行XRD检测，探究以上条件对DHHB结晶析出的影响，为解决后期开发防晒产品时的DHHB的应用问题提供指导意义。

Abstract:

This paper mainly studies the solubility changes of hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]-benzoate (DHHB), the most widely used sunscreen agent in different oils. Phenylethyl benzoate (226) oils have the greatest compatibility with DHHB sunscreens. After ultrasonic dissolution, the solubility is 0.241 g/mL when placed for 28 days at room temperature at 25 °C. The effect of different dissolution methods on the recrystallization of sunscreens was investigated, and it was found that the decline rate of the 28-day heating and dissolution was more than 10% lower than that of ultrasonic dissolution. It was reduced by 12.65%; the solubility changes of sunscreens were stored for 4 weeks under different storage temperatures (4℃, 25℃), and it was found that low temperatures were more likely to promote the crystallization of sunscreens. By adding emulsifiers Span 20 and Span 80, it is found that the addition of emulsifiers can significantly slow down the decline rate of the solubility of DHHB in the oil dioctyl carbonate (CC). The decline rate of the post-80s was reduced by 21.28%. By observing the crystallization behavior of sunscreen agents and XRD detection of recrystallized substances, the influence of the above conditions on the crystallization of DHHB was explored, which provided guiding significance for solving the application of DHHB in the later development of sunscreen products.