基于静电纺丝技术的农药传递体系的制备与性能表征

Preparation and characterization of pesticide delivery system based on electrospinning

摘要:

为获得一种新型高载药量、易分散型农药制剂，基于药物传递理论，以阿维菌素（AVM）为农药模型，以乙基纤维素（EC）为主要农药载体，以卡波姆（CB）为改性材料，利用静电纺纳米纤维载药技术构建一种具有微纳结构的农药传递体系。通过对复配比例、溶解参数及纺丝条件的探索，结果表明：采用N,N-二甲基乙酰胺与乙醇以体积比3∶1的混合溶剂对载体材料EC与CB分别进行溶解，EC与CB纺丝液的体积复配比为1∶1时，农药传递体系的载药量可高达35.7%，包封率接近100%，耐光解性大幅提升。并且，该农药传递体系的水分散性非常优异，具有长效释药性。

Abstract:

In order to obtain a new pesticide formulation with high drug loading and good dispersion property, based on drug delivery theory, a pesticide delivery system (PDS) with a special micro/nano composite structure was constructed by electrospinning technology with avermectin (AVM) as the pesticide model, ethyl cellulose (EC) as the main pesticide carrier, and carbomer (CB) as the modified material. Through the exploration of compound proportion, dissolution parameters and spinning conditions, the results show that: The mixed solvent of N, N-dimethylacetamide and ethanol was used to dissolve the carrier material EC and CB. When the volume complex ratio of EC and CB spinning solution was 1:1, the loading rate of AVM in PDS was up to 35.7%, the encapsulation rate of AVM in PDS was close to 100%, and the photolysis resistance was greatly improved. Besides, this PDS has excellent property of water dispersion, long duration of efficacy.